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2024 Jul 13];26(14)

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Neuroprotective responses activated due to loss of neural network and cell death were, the increased expression of the stress protein HSP70 (Du et al., 2012), chaperone GRP78 (Suyama et al., 2011), and of BDNF (Viwatpinyo and Chongthammakun, 2009

An increase in H 2 O 2 , the presence of other reactive species, or interference with the GSH redox cycle can result in an increase in oxidized glutathione (GSSG)

The popular claim that the effect fades after 4 to 6 weeks so you have to cycle is a widely repeated myth with no primary study behind it, and the mechanism actually argues against a classic tolerance effect