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Disease progression of IA is credited to the function of T cell adaptive immunity marked by dysregulated production of Th (T-helper cell) cell cytokines (176, 177)

Body size scalers and age factors were the most commonly identified covariates impacting busulfan PK in pediatric patients ( c standardized to 70-kg adult patient were 9.57 L/h and 28.2 L, respectively, which is consistent with previous studies ( To characterize developmental pharmacology, age-dependent physiological maturation functions were applied to describe changes in CL with age

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