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Increased ROS levels can regulate mitophagy via several pathways, NF-B, mTOR, p38-MAPK, SIRT, etc., For example, ROS (H2O2) accumulation results in NF-B inhibitor releasing in H2O2 oxidation manner, which activate NF-B signaling (Sies et al., 2017)

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However, scientists dont know much about how the virus helps these cancers evade the bodys immune defenses