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The fact that aaRS presents three distinct sites for their substrates (plus the editing site in some cases) and that rely on very specific contacts for tRNA binding provide multiple avenues that can be exploited to abort tRNA charging

S., Sabitha, S., Saravanakumar, K

10.3389/fnut.2022.994309 117 ManzoorM

[Google Scholar] 48.Horowski R

The ICV STZ-administered mice develop impairment of memory, advanced cholinergic discrepancies, hypometabolism of glucose in the brain, and oxidative stress, along with degeneration of neurons that leads to AD, which is associated with aggregated A plaques, tau protein, and A deposits