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Patients should weigh the high outofpocket cost ($100$300 per session) against the modest, often shortterm benefits reported in small studies, remembering that oral supplementation, balanced diet, sleep, and stressmanagement remain the most evidencebased ways to boost energy and overall wellness and supports lifestyle habits for lasting benefit.

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AMPK activation was also shown to selectively inhibit cancer cells that are deficient in the tumor suppressor gene p53 (Buzzai 2007)

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