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To integrate samples and mitigate batch-associated structure, we applied Harmony on the reduced-dimensional representation prior to downstream clustering and visualization 34

Together, they provide a comprehensive approach to skin health, addressing both underlying issues and structural integrity

In the case of glucocorticoids, both excess (Cushings syndrome) and insufficiency (Addisons disease) contribute to oxidative stress through a variety of mechanisms, such as decreased antioxidant defenses, increased reactive oxygen species (ROS) generation, and impaired mitochondrial function, which ultimately results in chronic inflammation

Despite it being generally safe and effective when following proper dosing and safety considerations, there are potential complications and risks one must be aware of: May cause bruising, bleeding, or infection at the injection site

Briley & Moret, 1993)