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Folinic acid also readily crosses the bloodbrain barrier and is slowly cleared, compared with folic acid, which is poorly transported into the brain and, once in the central nervous system (CNS), is rapidly cleared

So having two copies of C677T (or one copy of C677T and one copy of A1298C) really only increases the risks for certain problems

Membranes 11, 540

On the other hand, not only can GABA produced by the gut microbiota affect the CNS through pathways such as the vagus nerve 324 but also its excessive activation can inhibit dopamine release through GABA_A receptors on striatal neurons

Haschek and Rousseauxs Handbook of Toxicologic Pathology