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ABCB7 is misspliced and underexpressed in MDS-RS, due to somatic mutations in the splicing factor SF3B1

Therefore, the interaction between MB and NS goes beyond the interest in the sorption of MB onto NSs

given the very high rates of glutamine uptake by cancer cells 230 , oxidative decarboxylation of glutamine also proceeds to a significant degree

Taken together, these findings suggest that GNE-617 inhibits ADP-ribose production derived from the mitochondria, while disulfiram acts as an aconitase inhibitor within the TCA cycle