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The primary efficacy variable was the percent change of BMD at 24 Months relative to baseline

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Its toxic effects extend to male reproductive health, where it adversely effects on testicular function, impairs spermatogenesis, and induces oxidative stress through mechanisms such as elevating the Reactive oxygen species concentration, mitochondrial dysfunction, and cellular apoptosis which severely affects the reproductive health (74, 75)

This mechanism plays a crucial role in tissue regeneration and wound healing