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Andreassen and colleagues (J Med Chem, 2021) reported a design campaign that combined sequence substitutions to suppress fibrillation with a fatty-acid acylation that promotes albumin binding, yielding a molecule with a much longer reported plasma half-life in their preclinical models

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Co-Chairs/Speakers: John Jackson, Geophysicist, Environmental and Munitions Center of Expertise, USACE

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Together, the stack addresses both energy expenditure (AMPK) and fat accumulation (NNMT inhibition), creating synergistic metabolic effects that neither compound produces alone