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The underlying cause of deficiency is the most important determinant

Secondary outcomes included change in liver enzymes, liver fat, body fat, glycemic control and lipids

As tumors progress, symptoms may develop

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Elsevier, Amsterdam, pp 227287 Barth C, Moeder W, Klessig DF, Conklin PL (2004) The timing of senescence and response to pathogens is altered in the ascorbate deficient Arabidopsis mutant vitamin c-1