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ISBN: 9780124059450

After the impact, the influx of Ca 2+ ions into the cell cytoplasm leads to the phosphorylation/activation of phospholipases that cleave phospholipids into fatty acids, diaglycerols and lysophospholipids like LPC, which initiates signaling cascades that drive inflammation, BBB destruction, demyelination, and protein aggregation in several neurodegenerative contexts [81]

Moreover, a high-fat diet exacerbates oxidative stress in ocular surface epithelial cells, increasing the expression of enzymes like NOX4 and markers of nitrosative stress such as 3-nitrotyrosine (3-NT) [139]