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doi: 10.1111/ijcp.13998 84 PalanisamyGSKirkNMAckartDFShanleyCAOrmeIMBasarabaRJ

Dysregulation of the immune system impairs the function and number of Treg cells, which are essential for maintaining self-tolerance, while increasing the differentiation of proinflammatory Th1 and Th17 cells [34,35,36]