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acknowledges the support of the NIH (R01AG057497 and R01EY027789)

Activation of the Nuclear factor erythroid 2-related factor (NRF2), a redox-sensitive transcription factor which, in turn, promotes the activation of several biological systems encompassing anti-inflammatory molecules, antioxidants, drug metabolizing enzymes (including cytochrome P450s), and free radical scavengers, also plays a critical protecting role against OS(136-138)

coli MurQ-KU can be restored in the presence of fosfomycin when cells were provided with an alternative way to synthesize UDP-MurNAc via the AmgK/MurU pathway and supplemented NAM sugars 1 3 (Fig