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However, while FEV 1 is the primary endpoint in most clinical trials of mucus-targeted therapies, it is insensitive to early or small airway mucus obstruction [48] and correlates poorly with mucus plug burden on imaging [11]

7 , e2253 (2016)

Data analysed by two-way repeated measures ANOVA to assess main effects of treatment ( b , c , f , g , i and j )

We observed a similar pattern in GAPDH-deficient cells indicating that ATP depletion does not affect the gross morphology of the actin cytoskeleton

320 Although all cystines located on the surface of p53 can be modified by the Michael addition reaction, cystine 124 is considered the most important site