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McKinnell JA, Kunz DF, Chamot E, Patel M, Shirley RM, Moser SA, et al

Structurally it is ACTH 4-7 (Met-Glu-His-Phe), the melanocortin core of adrenocorticotropic hormone, extended at the C-terminus with Pro-Gly-Pro

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Specifically, Toll-like receptor (TLR) engagement by pathogen-associated molecular patterns (PAMPs) activates RIPK3 via the adapter proteins TRIF or ZBP1, thereby bypassing RIPK1 to directly promote MLKL phosphorylation and execute the necroptotic death program