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Xenobiotics may be detoxified in conjugation reactions with glutathione catalyzed by glutathione S-transferase, which activity is constitutive

Cancers (2020) 12:2085

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Roberts M.S

This neuroadaptation forms the mechanistic basis for withdrawal phenomena and explains why withdrawal symptoms tend to be predominantly hyperarousal in nature, including anxiety, insomnia, tremor, and autonomic symptoms

Health authorities discourage the use of BPC-157 due to insufficient human safety data, and it is not approved by any drug regulatory agency for human use