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In parallel, Zhao et al

doi: 10.3389/fnut.2024.1448388

Dues DJ, Tran Nguyen AP, Becker K, Ma J, Moore DJ

Norepinephrine and epinephrine are relatively small, highly polar molecules with primary amine groups that are fully protonated at physiological pH and show markedly negative distribution coefficients in aqueous buffer, indicating a strong preference for the aqueous phase 26,27,28,29,30