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The dose is deliberately high compared to classical peptides (5-10 mg for GLP-1 analogues, 2-5 mg for short regeneratives) because documented GHK-Cu protocols use larger quantities in trichological and cutaneous research (1-3 mg per injection, concentrated topical applications)

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FDA noted that an in-vitro pineal-gland study did not demonstrate a straightforward direct stimulation of melatonin release

The periodic solution in Panel B of Figure 3, GSH(t), is quite stable, fluctuating only between 5,500 and 8,000 M (even though the steady state values vary between 4,151 and 8,516 M)

National Library of Medicine, National Institutes of Health, U.S