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Thymosin beta-4 is a low-molecular-weight protein with a well-documented role in tissue repair processes, including wound healing, angiogenesis and peptide signaling, cellular proliferation and migration, re-epithelialization, and modulation of inflammatory responses

It appears to have been impactful in mice models of cardiac disease, where the life expectancy was reported to be increased by 27% compared to control animals

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The elucidation of signaling pathways involved in the regulation of the tight junction would allow the identification of novel barrier-restoring agents, which is imperative for deciphering novel and potent approaches for disease treatment