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After the initial infection of the skin (stage 1), the spirochete often disseminates to many sites (stage 2), particularly to other skin sites, the nervous system, heart or joints, where it might cause persistent infection (stage 3) for years

In fact, it has been observed that aberrant NFE2L2 transcript variants missing exon 2, or exons 2 and 3, are present in lung cancers and head and neck cancers

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Further analogues of bis-ester (IF-1) may be prepared by replacing the compound of formula (XIX) in Scheme A6 with a compound of formula (XIX-1) or (XIX-2) and then following the synthetic sequences described