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5-amino-1-methylquinolinium iodide as a highly selective inhibitor of nicotinamide N-methyltransferase (NNMT), effectively suppressing its catalytic activity and modulating key pathways involved in nicotinamide and cellular energy metabolism

J Chem Technol Biotechnol 83:11261134

FIGURE 10 In summary, PCs offer a multifaceted neuroprotective effect in DN by targeting oxidative and inflammatory pathways, preventing glycation-related damage, and reducing neuronal apoptosis