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SJS/TEN imposes clinical challenges for physicians managing patients suffering from this condition, both because it is rare and because it is a rapidly progressing systemic disease with severe cutaneous, mucosal, and systemic manifestations

Among them, thrombosis is a leading cause of death worldwide (Wendelboe & Raskob, 2016)

-4.5 IU/L (95% CI -8.5 to -0.4 IU/L, I 2 =45.2%) for ALT, and -10.7 IU/L (95% CI -14.9 to -6.5 IU/L, I 2 =48.9%) vs

Dopamine metabolism shifts in the same direction

Nat Nanotechnol 17:98106 Salminen A, Kaarniranta K, Kauppinen A (2013) Crosstalk between oxidative stress and SIRT1: Impact on the aging process