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While some polynitrosylated proteins, like bovine serum albumin (BSA), exhibited physiologic nitric oxide properties such as vasodilator and anti-platelet activities, nitrosylation of enzymes generally had an adverse effect on enzymatic activities

Furthermore, mitochondrial respiratory chain complex I activity was markedly reduced (Fig

10 The growth plate of the IR mutant mouse embryo exhibits a profound developmental delay in the appearance of ossification centers and severe growth deficiency (30% of normal size at birth)

Neuropharmacology 27:399408 De Boer T, Ruigt G, Berendsen H (1995) The 2-selective adrenoceptor antagonist org 3770 (mirtazapine, Remeron) enhances noradrenergic and serotonergic transmission

In physiological barriers such as the BBB, P-gp and BCRP are highly expressed and efflux exogenous toxins, exhibiting neuroprotective effects