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The progressive loss of neurons and synapses can lead to cognitive deficits, emotional dysregulation, and the manifestation of depressive symptoms, reinforcing the connection between chronic ethanol exposure, apoptosis, and depression

In a more recent randomized, open-label study in 45 RA patients, supplementation with a mixture of all three major curcuminoids (0.5 g/day for eight weeks) was found to be as effective as diclofenac (NSAID

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