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To reveal spectra of reaction states, SmTGR C31S (30.7 M) was mixed NADPH (30.27 M) and the reaction monitored using CCD detection

Like in mouse sepsis, Nr1i3 and all CAR target genes investigated were downregulated in pig sepsis, although the downregulation was generally less pronounced in pigs than in mice, except for NR1I3 and the CYP genes ( Figures 10A, B )

GSH depletion will lower a cell's capacity to buffer against endogenous oxidants, and it may set a time limit on continued mitochondrial function and thus indirectly on total ATP levels and membrane integrity