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Glutathione oxidation by hypochlorous acid in endothelial cells produces glutathione sulfonamide as a major product but not glutathione disulfide

Even though the underlying pathways that mediate the development of tubulointerstitial lesions in diabetic nephropathy are not well understood, previous studies have suggested that TGF-1 is the principal mediator of the deleterious effects of the diabetic milieu 11

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