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Funding This work was supported by National Science Centre in Poland, grant number 2014/15/B/NZ7/00893

The second stage involves coupling pesticide metabolites to sugars, amino acids, or glutathione by glutathione-S-transferase (GST) and uridine diphosphate UDP-glycosyltransferase (UGT), which is less toxic and more soluble in water

I.AndradeR

2001 Sep;132(3):311-20

After 6 hours (which equals 6 half-lives), the maximum and minimum drug concentrations become constant, further drug accumulation does not occur, and the drug is steady-state