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The degradation rate and half-life (t1/2) of the drugs were determined by measuring the decrease in area under the curve (AUC) at their retention times [1]

Acknowledgements This research was supported by the key program of the Natural Science Foundation of China (NSFC) (32030091, Z.Z.), the Jiangsu Provincial Excellent Youth Science Foundation (BK20230100, M.L.), the NSFC Program (32172377, M.L.), the Innovational Fund for Scientific and Technological Personnel of Hainan Province (324CXTD428, Z.Z.), the Jiangsu Agriculture Science & technology Innovation Fund Program [CX(23)1032, Z.Z.], and the Biological Breeding-National Science and Technology Major Projects (2023ZD04070, L.Y

Rapamycin also decreases cell viability and increases iron content and ROS generation (13)

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