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Zhang and Cuervo (122) maintained LAMP2A activity in aged transgenic mice using Tet-regulators (responsive to tetracycline or its derivative doxycycline), observing reductions in liver damage markers, apoptotic cells and undegraded damaged products in the lysosomal compartment

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Its antitumor effects include its antioxidant activity, inhibition of angiogenesis, inhibition of the cell cycle and proliferation, and prevention of tumor metastasis