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This has been discussed in the next section so that readers can perceive the underlying concepts behind the development of pathways that contribute to drug resistance in cancer cells [11,12,13,14]

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10.1016/j.rmed.2016.06.015 Respir

By inhibiting NNMT, it leads to an increase in intracellular levels of NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme for cellular metabolism and mitochondrial energy production

To date, NACA has been shown to have antioxidant activity in several preclinical models, but is yet to be approved for clinical use