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10.1056/NEJMra1106180 N Engl J Med

Binding to antioxidant response elements (AREs) induces the transcription of genes regulated by AREs, which initiates the expression of genes encoding cytoprotective enzymes, such as antioxidative stress proteins, especially antioxidant enzymes ( Figure 2 The antioxidant response is also modulated by signaling pathways mediated by adenosine 5'-monophosphate-activated protein kinase (AMPK)

NAC, in particular, has been shown to increase glutathione levels in the liver and other tissues (1)

CD36 is thought to be involved in the initiation of metastasis [77] and the promotion of fatty acid -oxidation to support proliferation [78]

Redox modulation of the apoptogenic activity of thapsigargin