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Therefore, iron overload and its induced depletion of Bifidobacterium , along with intestinal dysfunction, form a synergistic effect on the gut-joint axis. By exacerbating local ferroptosis and systemic inflammation, they may synergistically contribute to the pathogenesis and progression of OA

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BPC-157 increases VEGF expression explaining improved revascularization in injured tissues

aureus are the major causes of death associated with AMR in high-income countries such as North America, Western Europe, and Australia

Depletion of SIRT2 decreases total GSH level and meanwhile increases the cellular susceptibility to ferroptosis, which can mostly be rescued by introducing wild-type GCLC, but not its 3K-E mutant