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When the interaction of compound 36 with the protein was examined by the simulation, it was observed that it had significant hydrophobic interactions, especially with Tyr70, Trp84, Phe331, Phe330, Tyr334, Trp279, Tyr121, and His440 (Fig

PXR has been shown to induce the expression of multiple key components in the clearance pathway of bile and bilirubin, including UGT1A1, OATP2, GSTA1 and 2 and MRP2 [1]