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5.4 Mitochondrial dysfunction as an upstream driver of amyloid and tau pathology A significant shift in Alzheimer's disease (AD) research is represented by the Mitochondrial Cascade Hypothesis, which posits that mitochondrial dysfunction is the primary driver of AD pathophysiology, rather than a secondary consequence of Tau or A accumulation (94)

Acknowledgements The authors are thankful to Integral University, Lucknow, and Eras Lucknow Medical College and Hospital, Era University, Lucknow for providing their assistance during this work

This is a dramatic simplification, of course, but it captures the essence of its function

Get the details in the Concerns and Cautions section of our Acetyl -L-Carnitine Review

2) Does an overdose of glutamate in the cerebrospinal fluid reflect on the blood level of glutamate