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Current FDA labeling for semaglutide products includes warnings or precautions involving: Acute pancreatitis Acute gallbladder disease Acute kidney injury due to volume depletion Severe gastrointestinal reactions Hypoglycemia when combined with insulin or insulin secretagogues Diabetic retinopathy complications in susceptible patients Serious hypersensitivity reactions Pulmonary aspiration risk during general anesthesia or deep sedation Semaglutide labeling also contains a boxed warning regarding thyroid C-cell tumors observed in rodents

Vandesompele, J

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DOI: 10.1023/a:1020107915919 74

Patients in IKEMA appeared more likely to have high-risk cytogenetics, though a higher percentage of patients in CANDOR had unknown cytogenetics at baseline compared with IKEMA (51 vs