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Additionally, iron deposition correlates with disrupted axonal transport and mitochondrial dysfunction (352, 355)

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Ligand-SOD Receptor interactions The interaction of the ligand with the SOD receptor is exhibited with the formation of five hydrogen bonds

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It was observed that azide produced graded increases in ROS signaling, accompanied by graded decreases in contraction that were reversible, demonstrating that mitochondria respond to graded hypoxia by increasing the generation of ROS and suggesting that cytochrome oxidase may contribute to this oxygen sensing mechanism [71]