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16 ChenJ.YanL.ZhangY.LiuX.WeiY.ZhaoY.et al (2024)

Our results suggest that just as mitragynines metabolism to 7-hydroxymitragynine results in greater activity at -opioid receptors, 11 paynantheines and speciogynines activity at 5-HT 1A Rs and 5-HT 2B Rs may be principally mediated via their metabolites, 9- O -desmethylspeciogynine and 9- O -desmethylpaynantheine