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Nonetheless, only micromolar amounts of glutathione are required for Fe-S cluster biogenesis and the biological reason for the millimolar concentrations of glutathione present in cells across eukaryotic kingdoms remains unclear [58]

"Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice." Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1773(6): 990999