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10.1042/bsr20203857 136 TanL

Results: Unbiased scRNA-seq identified 25 clusters and immunosuppressive M2 tumor-associated macrophage (TAM) and exhausted PD1+CD8T cell clusters were enriched in steatotic livers

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The text also covers representative drugs of the major biologics currently used in the treatment of HS and describes the IRAK4 inhibitor Zimlovisertib and the IRAK4 degrader KT-474, along with a discussion of the current status of drugs that inhibit IRAK4 in the treatment of HS and the challenges they face