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In a cecal ligation and puncture rat model, it specifically inhibited peptidylarginine deiminase 4 (PAD4), a key enzyme for histone citrullination and NETs release, thereby improving coagulation parameters and reducing the microcirculatory thrombus burden (Zhang et al., 2025)

*Correspondence: Linda de Bont, [email protected] Rouhier, [email protected] This article was submitted to Plant Abiotic Stress, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, this cause-agnostic approach does not fully encapsulate the heterogeneity of DCM and a growing body of data support an increased risk of SCD with specific genotypes

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