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This overload is primarily mediated by the inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) located on the ER membrane (see Figure 2 ) (45), evidenced that bombesin can enhance the gene expression of IP3Rs and RyRs, causing calcium overload, while docosahexaenoic acid can inhibit this process, thereby restoring normal calcium signaling within acinar cells (46)

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