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High levels of UTP suppress the production of pyrimidines, ensuring balance with other nucleotide pools

Activity of cytotoxic lymphocytes in the tumor may also be antagonized due to the abnormal nature of tumor vasculature (107109)

An in vitro study examined the expression levels of LXR-target genes using real-time RT-PCR

Am J Physiol Heart Circ Physiol 325:H398H413

Drugs with a Vd value of less than 0.3 L/kg are predominantly confined to the ECF, whereas drugs with a Vd value of greater than 1 L/kg are highly lipid soluble and tend to distribute out of the extracellular fluid and into tissue compartments (Box 4-1)