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They impact synthesis by modifying enzyme activation or gene transcription for hormone precursors and secretion by changing vesicle release mechanisms

Thus, a higher glutamine/glutamate ratio reinforces the substrates availability for GSH synthesis [39]

In vivo , ADO concentrations in BM plasma remained consistently in the micromolar range and declined only modestly during treatment, whereas INO progressively increased, leading to a gradual attenuation of the BM -PB gradient