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Strategies targeting BH 4 regeneration via guanosine triphosphate cyclohydrolase (GPTCH) or the BH 2 -reducing enzyme, dihydrofolate reductase (DHFR), may help preserve eNOS function [139, 140]

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It showed similar tendency with MDA contents, suggesting that a lower degree of lipid peroxidation is closely associated with a higher level of anti-oxidant enzyme activity