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Feldman HA, Papageorge MV, Deboever N, Goodrum H, Camp S, Blackmon S, Lawton JS, Antonoff MB

doi: 10.16438/j.0513-4870.2011.04.013 152 GheitaHAEl-SabbaghWAAbdelsalamRMAttiaASEl-GhazalyMA

Note that MPA cannot be used in sham rat but just in PNI injured animals

Thus, under circumstances of SAM excess homocysteine cannot be catabolized to cysteine and accordingly accumulates as cystathionine in brain ( There is also evidence for additional regulatory mechanisms for the co-ordination of remethylation and transsulfuration