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In particular, exosomes derived from HEK293 cells treated with interferon- (INF-) carry a higher amount of OCTN2 with respect to exosomes derived from untreated cells

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Randomized controlled trials in healthy individuals, however, have not shown vitamin E supplements to be effective in preventing heart attacks or death

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In preclinical models, acetyl-L-carnitine reduced brain oxidative damage markers including malondialdehyde, oxidized nucleotides, and nitrotyrosine, while L-carnitine at equivalent doses did not, despite both similarly elevating tissue carnitine levels and improving ambulatory activity.[1] Acetyl-L-carnitines superior CNS effects likely reflect its ability to donate acetyl groups for energy production, neurotransmitter synthesis, and direct antioxidant activity.[2][3] For systemic inflammation, L-carnitine demonstrates clear clinical efficacy