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A deficiency can lead to fatigue, increased susceptibility to infections, or muscle weakness

10.1038/s41467-018-06004-8 173 SieghartW.SperkG

Primary endocrine resistance was defined as relapse while on the first 2 years of adjuvant endocrine therapy (ET) and secondary endocrine resistance was defined as relapse while on adjuvant ET after at least 2 years or relapse within 12 months of completing adjuvant ET

Crohn's disease can affect any part of the digestive tract, from the mouth to the anus, although it most commonly affects the end of the small intestine (ileum) and the beginning of the large intestine (colon)

Curr Top Cell Regul