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In the present study, given that signaling through both VEGFR1 and VEGFR2 is crucial for tumor angiogenesis, growth and metastasis 20 , a linear peptide was rationally designed from 2-3 loop (loop1) and 5-6 loop (loop3) of VEGF-B as well as 5-6 loop (loop3) of VEGF-A, according to their complex with VEGFR1 D2 and VEGFR2 D2