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The findings confirm previous results from a Phase 2/3 trial and point to ultrahigh-dose methylcobalamin as a potential new therapy for early-stage ALS

References: National Institute for Health and Care Excellence (NICE)

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2e, f, 6a), while the conserved His108 ( Sas Pcob numbering) provides the lower axial ligand to the Co atom of the B 12 cofactor (i.e., base-off His-on ligation, Fig